October 23, 2021

Biology Reporter

Complete News World

Alzheimer's disease and liver health.  important discovery

Alzheimer’s disease and liver health. important discovery

Researchers at Curtin University in Bentley, Australia, believe that a specific protein produced in the liver can cause neurological deterioration in the brain. It’s about amyloid – a harmful starch-like protein that is formed in a long process of debilitating disease. High levels of beta-amyloid protein fragments in plasma are associated with faster memory loss, even in people without Alzheimer’s disease.

Amyloid beta proteins – a pathological feature of Alzheimer’s disease

Since protein is believed to be a major factor in the development of Alzheimer’s disease, the findings suggest that the liver may play an important role in the onset or progression of the disease. Scientists tested the hypothesis that high levels of amyloid beta (A-beta) may contribute to Alzheimer’s disease. The tests were difficult because the brain also produces the same protein, and it is difficult to distinguish between them. Laboratory rats tested came to the rescue.

The study authors modified mice cells to produce only human beta in liver cells. It was carried in the blood and transmitted to the brain as in humans. Mice were found to develop neurodegeneration and brain atrophy accompanied by neurovascular inflammation and capillary dysfunction in the brain. Both symptoms are commonly seen in Alzheimer’s disease. The affected mice performed poorly on cognitive tests related to the hippocampus.

Take care of your liver so you don’t get sick

The results indicate that overproduction of beta has the potential to induce neurodegeneration and may contribute to human disease. Importantly, the overproduction of A-beta in the brain is no longer critical—scientists tend to favor higher levels of the protein in the liver. A healthy lifestyle and low-fat diet can prevent this – in other words, keep your liver looking its best.

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“This result shows that the abundance of toxic protein deposits in the blood can be countered by diet and certain medications (which target amyloid lipoprotein), thereby reducing the risk or slowing the progression of Alzheimer’s disease,” explained lead researcher Dr. John Mamo. Author of Curtin University Study Book.

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