September 22, 2021

Biology Reporter

Complete News World

Ammonia – study, standards. For a healthy liver

Ammonia is produced in the human body as a result of metabolic changes. It is one of the compounds that is a by-product of the transformation of proteins and amino acids supplied by the body. This compound is converted to urea and then eliminated with urine. An excess of ammonia in the blood leads to serious disturbances in the functioning of the body, which indicates, inter alia, to: liver disease.

What is ammonia?

Ammonia is an inorganic chemical. Contains nitrogen and hydrogen. Incorrect transformations of ammonia disturb the course of many life processes. Ammonia is a toxic compound, so it is converted in the human body into urea, which belongs to the group of products of nitrogen metabolism. The conversion of ammonia to urea and its excretion from the body is known as ureotelism.

Ammonia in the human body

Ammonia is produced by living organisms. In the case of the human body, its molecules are a byproduct of the metabolism of proteins and amino acids. Ammonia formed in the human body is also called non-protein nitrogen. It must be effectively converted into urea and removed from the body, which is associated with a very toxic effect, among other things. on the human nervous system.

A healthy liver is necessary to effectively remove ammonia from the body by converting it to urea. Excess nitrogen compounds in the blood which include, among others, ammonia is an important diagnostic indicator.

Ammonia – Study

The ammonia test in blood serum allows you to assess the efficiency of the liver and the effectiveness of the body’s detoxification processes, thanks to which harmful by-products of metabolism are removed from the body. Thanks to the analysis of the blood taken for the test, it is possible to check the efficiency of the liver parenchyma and to detect various abnormalities related to this organ, which lead to severe damage to the central nervous system. Disorders of ammonia catabolism (conversion of this compound) can lead to death.

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Often, laboratory tests allow to detect high levels of ammonia in the blood, which indicates serious disorders in the work of the liver or failure of this organ of various origins. Ammonia that is lower than normal is rarely diagnosed, but in this case also indicates disturbances in the functioning of the organism. Low ammonia level is a symptom of problems maintaining normal blood pressure – it may indicate, among other things, treatment of essential hypertension and malignant hypertension.

Venous blood is collected to test the level of ammonia in the blood. It should appear on an empty stomach (after at least 8 hours of fasting); For 48-72 hours before the examination, heavy physical exertion or smoking should be avoided.

Ammonia – Standards

Standards for ammonia are set for women, men and adult children. The normal range for adult women is 15 to 60 mEq/L; The normal range for adult men is 10 to 50 mEq/L.

Reasons for high levels of substances in the blood:

High ammonia levels can be a result of congenital and acquired diseases, and it can also be related to our lifestyle. An increase in the level of ammonia, or hyperammonemia, is a health and life-threatening condition. The most common causes of high levels of ammonia in the blood are:

• Disorders in the work of the liver including. hepatic encephalopathy,

• hemolytic diseases,

• Congenital metabolic disorders.

• Kidney problems.

An elevated serum ammonia level may also be associated with, among other things, heavy cigarette smoking, prolonged intense physical exertion and fasting use.

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