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Complications after COVID-19. Cognitive and behavioral disorders in patients

Complications after COVID-19.  Cognitive and behavioral disorders in patients

These conclusions were made, among other things, by scientists from Universita Vita-Salute San Raffaele in Milan, who tested the neurocognitive abilities of patients who were discharged from hospital two months ago after contracting COVID-19. They also had a brain magnetic resonance imaging (MRI) scan.

It turns out that more than 50 percent. Of the respondents had cognitive impairment: 16% had problems with so-called executive functions, such as information processing, working memory (allowing temporary information to be stored and processed), and creative thinking, 6% had problems with spatial orientation (such as problems with assessing depth or perceiving inconsistencies), 6% had poor memory, and 25 percent. Show a combination of these cognitive problems.

Additionally, a fifth of COVID-19 patients have PTSD, and 16% had symptoms of depression.

Cognitive and psychological problems were more severe in young adults. Executive dysfunction has been associated with more severe and acute respiratory symptoms in patients during their hospital stay.

Moreover, observation of the same group of patients showed that after 10 months, the proportion of people with cognitive impairment decreased from 53%. Up to 36%, but symptoms of PTSD and depression persisted.

– Our study confirmed that significant cognitive and behavioral disturbances are associated with COVID-19 and persist for several months after the infection resolves – commented the lead author of the study, Professor. Massimo Felipe.

As he noted, the executive function disorders his team noted are particularly worrisome, which may impede focus, planning, creative thinking and remembering. – These symptoms occurred in three out of four patients of working age – the professor emphasized. Philippe.

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No relationship was found between cognitive problems and brain size.

Scientists stress that more extensive research is needed, with longer time to monitor patients’ health. In their opinion, patients after COVID-19 may need adequate support and help in relieving neuropsychiatric symptoms.

Several other studies were also presented at the conference in Vienna that showed that neuropsychiatric symptoms may persist after COVID-19.

A team of researchers from Osperdale Maggiore Policlinico in Milan showed in a group of 53 patients that more than 77 percent of patients. They included at least one neurological symptom between 5 and 10 months after being hospitalized with COVID-19. In more than 46 percent there were more than three neurological symptoms. The most common are: insomnia, daytime drowsiness, and trouble walking. Headaches were less common, decreased ability to sense smells (decreased sense of smell) and loss of taste. As scientists note, 90 percent. Of those surveyed developed some symptoms after contracting COVID-19, of which neurological symptoms were an important part.

In turn, in a study conducted by a team of Ukrainian scientists led by Prof. Named after Tamry S. Miszenko from Kharkiv National University Vasyl Karazin with 95 percent. Of the 42 patients who were followed two to four months after hospitalization for COVID-19, they developed neurocognitive symptoms. The ages ranged between 32 and 54 years. They were all weak and extremely tired. They also showed symptoms of depression and anxiety. Among other symptoms, the researchers reported: imbalance (59.2%), headache (50%), and poor ability to perceive smells (19%). Five patients also had a stroke after a two-month stay in the hospital.

In turn, Italian researchers under the supervision of Dr. Tommaso Bucchi of the University of Milan tested postmortem brainstem damage in 19 patients with COVID-19. They showed that it contains an increased amount of amyloid deposits, which are characteristic of neurodegenerative diseases. Furthermore, immunohistochemical tests revealed the presence of SARS-CoV-2 in the brainstem. As part of the review, results were compared to the brains of patients who died in intensive care from other causes. According to the study authors, this suggests that respiratory failure in the context of COVID-19 may be related to brainstem infection with MERS-CoV.

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