Amylase is an enzyme responsible for breaking down complex sugars found in human pancreatic juice and saliva. A level test is useful in diagnosing pancreatitisBecause it allows you to check that the device is working properly.
Good to know Damage to the pancreas also leads to a disruption in the production of other enzymes, such as lipase, elastase, insulin and glucagon.This is reflected in the results of laboratory tests. Amylase breaks down the bonds in the polysaccharide molecules, allowing them to be broken down into smaller pieces, which is a necessary condition for the digestion process to occur properly.
Due to the fact that pancreatic amylase is produced by the exocrine cells of the pancreas, it can be treated as an inflammatory marker when it enters the blood as a result of blockage or necrosis of cells. About 10 hours after its appearance in the plasma, the enzyme is excreted in the urine, soAboratoria also means its level in urinewhich serves to confirm the history of pancreatitis, especially since the increased concentration of large amylase persists in the urine and not in the blood.
Determination of the level of pancreatic amylase is often performed in patients with suspected acute or chronic pancreatitis. The most common conditions responsible for these diseases include: gallstones, alcoholism, high levels of adrenaline due to long-term stress, hyperlipidemia, taking certain medications (eg, non-steroidal anti-inflammatory drugs, azathioprine or diuretics), as well as endoscopy. Reverse bile duct imaging.
Symptoms that may suggest pancreatitis and that should be an indication for measuring the level of amylase are:
- epigastric pain
- blood in stool
- Unintended weight loss
- Flatulence, nausea and vomiting.
The amylase test is also used in cases of suspected gastric or duodenal ulcer as well as ischemia and intestinal obstruction.
In order to determine the level of amylase, it is necessary to take a venous blood sample. Study patients should fast and abstain from alcohol and certain medications, especially those containing calcium, the day before. Results may also be affected by gastroscopy or fluorography with a contrast agent, and women taking contraceptives should inform the referring physician of this fact.
When acute pancreatitis is suspected, the timing of the examination is very important, preferably within 12 hours of the onset of the first symptoms.
The standard is when Amylase ranges from 25 to 125 IU/L. In the elderly, this limit is slightly changed and ranges from 20 to 160 IU / l.
A decrease in the level of amylase may be a signal of damage to the pancreatic parenchyma, It can be caused by: chronic pancreatitis, preeclampsia, heart attack, liver damage or cystic fibrosis.
However, amylase abnormalities are usually elevated amylase levels as the enzyme escapes from the exit channels due to inflammatory processes.
As a result, amylase levels increase:
- acute pancreatitis;
- Salivary gland inflammation.
- Renal failure;
- Obstruction of the intestine or pancreatic ducts.
- autoimmune diseases;
- Abdominal injuries
- Certain genetic conditions (eg, macamylasemia)
- ectopic pregnancy;
Chronic stress also affects the level of amylase, so the level of this enzyme should be checked for people who suffer from it. Please note that Long-term stress leads to an increase in the level of adrenaline and an increase in the production of digestive enzymes, including amylase.. Of course, it contributes to the development of digestive problems such as chronic constipation, diarrhea, mucositis or peptic ulcer disease.
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