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Scientists have changed the behavior of hamsters. They used CRISPR/Cas9 technology

Scientists have changed the behavior of hamsters.  They used CRISPR/Cas9 technology

Use CRISPR/Cas9 . gene editing technologyScientists at Georgia State University have successfully eliminated the influence of a neurochemical signaling pathway that plays a key role in regulating social behavior in mammals. vasopressin And the future he’s working on is called Avpr1a Organizing social phenomena from association, cooperation, and social communication to domination and aggression.

New research shows that inactivating Avpr1a receptors in hamsters is effective Elimination of the effect of vasopressin On this future, the expression of social behavior unexpectedly changed.

– We were really surprised by the results. We expected that if we exclude vasopressin activity, we would reduce both aggressiveness and sociability. But the opposite happened – said Prof. Elliott Albers of Georgia State University.

Hamsters that suffer from a lack of receptors showed a significantly higher level of social communication behaviors than their counterparts with undamaged receptors. Most interestingly, the typical sex differences observed in aggression were eliminated – both male and female hamsters showed high levels of aggression towards other animals of the same sex.

– This indicates a surprising result. Although we know that vasopressin increases social behavior by acting in multiple brain regions, it is possible that the more extensive action of the Avpr1a receptor is inhibitory in nature. We do not understand this system as we thought. The counterintuitive findings show us that we need to start thinking about the action of these receptors in the entire periphery of the brain, and not just in specific areas of the brain, the professor explained. Albers.

Search has been used Syrian hamsterWhich is gaining increasing importance in the search for social behavior, aggressiveness and communication. They are the species in which vasopressin has been shown to influence social behavior for the first time. The hamster is an excellent model for studying social behavior because its social organization is more similar to humans than it is to mice, despite the fact that mice are the most frequently used laboratory animal.

Their response to stress is more similar to that of humans than that of other rodents. They secrete the stress hormone cortisol, just like humans. They also have a lot of cancers that people have. Professor C. Albers.

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